Brain and Aging

Nutrients, Microglia Aging, and Brain Aging.

As the life expectancy continues to increase, the cognitive decline associated with Alzheimer's disease (AD) becomes a big major issue in the world. After cellular activation upon systemic inflammation, microglia, the resident immune cells in the brain, start to release proinflammatory mediators to trigger neuroinflammation. We have found that chronic systemic inflammatory challenges induce dif...

Insulin and brain aging

The world's population is living much longer than in the past. It is crucial to find as many pathological factors that deteriorate the health condition and well-being of elderly people as possible. Loss of activity and functions over time is typical for elderly people. Aging affects brain function, metabolism and structure in different ways, and these effects have multiple etiologies. Cognitive...

Brain Connectivity and Aging

here is growing evidence that in the aging process both the neural and the vascular aspects of brain function are affected. On the neural side, aging is associated with damage to the myelin sheaths and reduction in the total number of nerve fibers, resulting in a reduction in structural connectivity [1]. But connections in the brain are not only structural (i.e. synapses, axons, etc.); equally ...

BubR1 and brain aging

[Inflammation and brain aging].

The review covers current concepts on cell and molecular mechanisms of neuroinflammation and aging with the special focus on the regulation of cytokine-producing activity of astroglial cells and intercellular communication. The review reflects that a key component of the aging phenomenon as a result of ineffective implementation of anti-inflammatory response are processes of the dysregulated cy...